Results from a
study presented at the San Antonio Breast Cancer Symposium showed patients with
metastatic, HER2-positive breast cancer
who received a combination antibody/chemotherapy drug in a phase 3 clinical
trial survived longer, on average, than patients receiving other treatments. (http://news.cancerconnect.com/conjugate-drug-extends-survival-in-patients-with-advanced-her2-positive-breast-cancer/
)“The TH3RESA trial, which enrolled
more than 600 participants in the U.S. and overseas, compared survival times in
patients randomized to treatment with the conjugate drug trastuzumab emtansine
(T-DM1) to those randomized to treatment of their physician’s choice. All
patients had metastatic breast cancer that tested positive for the human
epidermal growth factor receptor 2 (HER2) protein – a feature in about 20
percent of all breast cancers – and had previously been treated with
chemotherapy as well as the HER2-targeted drugs trastuzumab and lapatinib. The
investigators found that those in the T-DM1 group lived a median of 22.7 months
vs. 15.8 months for those in the treatment of physician’s choice group – a 44
percent improvement.” In addition,
serious side effects were lower in the TDM-1 group. |